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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 9, Issue 1, November 2013 pp 136-141

Research Article

Assessment of Conception Rate in Infertile Couples with Genital Tuberculosis Diagnosed with Multiplex Polymerase Chain Reaction

 Anjali Patil1, R. P. Patange2

{1Assistant Professor, 2Professor and HOD} Department of OBGY, KIMSDU, Malkapur Maharashtra INDIA.

Academic Editor : Dr. Aher K.R.



Objective: Mycobacterium infections of genital tract of couple have an impact on fertility. Both suspected male or female were subjected to investigation of genital TB and treating the affected or the couple and rise in pregnancy rate was studied. Methods: After detailed history and investigations to rule out other causes of infertility in couple both husband and wife who were strongly suspected of genital tuberculosis were tested by multiplex Polymerase chain reaction(PCR) technique for confirming evidence of genital tuberculosis. The affected individual or both husband and wife were treated effectively by antitubercular therapy and results were correlated in terms of pregnancy outcome. Results: Out of 229 couples studied 208 females and 99 males were diagnosed of having latent genital tuberculosis with multiplex DNA TB PCR test. After ATT pregnancy outcome was studied. Overall pregnancy rate was 135 (59%).  The spontaneous conception rate was 91 (67.4 %) within 6 months of ATT. This rate is much higher compared to other studies in which only the female partner was diagnosed and treated for genital tuberculosis. Conclusion: The diagnosis of genital tuberculosis is very difficult. It is considered as severe form of extrapulmonary tuberculosis. This silent invader creates diagnostics dilemmas. But accurate diagnosis of early genital tract tuberculosis in one or both partners and treatment accordingly has given infertile couple an excellent chance for spontaneous conception.