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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 9, Issue 1, November 2013 pp 144-145

Research Article

Study  of  Serum  TSH  and  Prolactin  Levels in  Patients  of  Female  Infertility

Manjusha D. Hivre^*, Dhananjay V. Bhale^**, Roshan K. Mahat^***, Ashlesha A. Bujurge^***

^*Assistant Professor, ^**Professor and HOD, ^***PG Students, Department of Biochemistry

Academic Editor : Dr. Aher K.R.

Background: The prevalence of infertility is estimated between 12 and 14 % and remains stable in recent years. Female causes of infertility comprise of endometriosis, tubal damage and ovulatory dysfunction. Thyroid dysfunction itself is a condition interfering with normal ovarian function. Hypothyroidism can affect fertility due to anovulatory cycles, luteal phase defects, hyperprolactinemia, and sex hormone imbalance. Aims and Objectives: Study  of  Serum  TSH  and  Prolactin  levels in  patients  of  female  infertility  and  in normal fertile females. Materials and Methods: This study was undertaken  in Department  of Biochemistry MGM medical college, Aurangabad .A total of 50 infertile women visiting for the first time gynaecology OPD at MGM medical college, Aurangabad (M. S.) for infertility were investigated for thyroid stimulating hormone (TSH) and prolactin (PRL). 50 fertile women with similar age and socioeconomic status were enrolled as the controls. Results: The prevalence of hypothyroidism was slightly higher in the infertile group in comparison with that of the general population. There was a positive correlation between serum TSH and prolactin levels in the infertile subjects. Menstrual disorders (mainly oligomenorrhea), were reported by about 70% of the infertile women. Hyperprolactinemia was depicted in 51% of the infertile women while it was only 10% in the control group. The infertile women with hypothyroidism had significantly higher prolactin levels when compared to the subjects with fertile women. Conclusion: There is a greater propensity for thyroid disorder in infertile women than the fertile ones. There is also a higher prevalence of hyperprolactinemia in infertile patients.