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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 9, Issue 1, November 2013 pp 155-156

Research Article

Study of Oxidative Stress in Patients of Pregnancy Induced Hypertension


Dhananjay V. Bhale*, Roshan K. Mahat**

*Professor and HOD, **PG Student, Department Of Biochemistry, MGM Medical College, Aurangabad, Maharashtra, INDIA.

Academic Editor : Dr. Aher K.R.



In Pregnancy Induced Hypertension many complex homeostatic modifications occur, some are harmful to the mother and foetus, while others are beneficial. Lipid peroxidation is an important causative factor in the pathogenesis of pregnancy induced hypertension.  Pregnancy Induced The objective of this study was to determine the serum Malondialdehyde (MDA) as a marker of oxidative stress in pregnancy induced hypertension (PIH) and to compare them to that of normal pregnant women. Materials and Methods: The study was carried out in the department of Biochemistry which included total 30 patients of Pregnancy Induced Hypertension (PIH) age group of 20-40 years and age and sex matched controls. Serum maondialdehyde (MDA) was estimated by method of Nourooz-zadeh J et al. using trichloro acetic acid and thiobarbituric acid. Mean and standard deviation were calculated for Serum MDA. Statistical analysis was done using SPSS no. 17 and student t test. In the present study, statistically significant increase in levels of lipid peroxidation(MDA) was observed PIH as compared to those in normal pregnant controls.