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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 9, Issue 1, November 2013 pp 157-158

Research Article

Study of Oxidative Stress in Patients with Hypertension

Dhananjay V. Bhale^*, Manjusha D Hivre^**, Roshan K Mahat^***,Aasiya   Saudagar^***, Devendra Mishra^***

Ashlesha Bujurge^***

^*Professor and HOD, ^**Assistant Professor,^***PG Student, Department of Biochemistry

MGM Medical College, Aurangabad, Maharashtra, INDIA.

Academic Editor : Dr. Aher K.R.

Background: Hypertension is correlated with the incidence of atherosclerosis. Hence, present work was undertaken to investigate the association of Blood pressure and lipid peroxidation in hypertensive patients. Objective: To study the levels of serum MDA as a marker of oxidative stress in patients of hypertension. Methods: In this cross sectional study 30 normotensive and 30 hypertensive subjects were included. The potential participants were subjected to selection protocol consisting of clinical history, physical examination and appropriate test. All subjects underwent blood pressure measurement and markers of oxidative stress were estimated in serum. Results: There was a significant increase (p=0.0001) in the SBP, DBP in Nonhypertensive Controls. The MDA level was significantly increased (p=0.05) in hypertensive patients. Conclusion: Present study showed strong association of oxidative stress with high blood pressure and there was positive correlation between marker of oxidative stress and systolic and diastolic blood pressure.