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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 9, Issue 2, December 2013 pp 199-204

Research Article

Serum Uricacid Estimation in Acute Myocardial Infarction - A Prognostic Indicator

Gandiah P.¹, Venkateshwarlu N.², Naveen Kumar M.³, Indira G.⁴, Sivarajappa P.⁵

¹Professor and H.O.D., ^2,4,5Professor, ³Ex-Post Graduate Student

Academic Editor : Dr. Aher K.R.

Background: Elevated serum uric acid is highly predictive of mortality in patients with heart failure or coronary artery disease and of cardiovascular events in patients. Large cohort studies have shown that uric acid is an important independent risk factor for cardiovascular mortality. The role of uric acid in coronary heart disease is less clear. Some studies reported an independent association between uric acid and coronary heart disease. Material and Methods: 100 cases of AMI were studied in this study. 50 age and sex matched individuals without any ailments served as control group. Serum uric acid levels were estimated on days 0 and 7 apart from various relevant investigations. The study group was classified into one of the four Killip class. The study was approved by the college ethics committee. Observations: There was a statistically significant higher level of serum uric acid concentration in patients of AMI on day of admission as compared to controls (P< 0.05). There was no significant difference in serum uric acid levels as regards  hypertension and diabetes mellitus in patients with AMI, but there is a statistically significant(p=0.0001) difference in serum uric acid levels in patients with past history of IHD or stroke. On all the days serum uric acid levels were higher in patients who were in higher Killip class (P< 0.05). All the patients who died were in Killip class IV and all had serum uric acid concentration ≥ 7mg/dl. It had been concluded that alone serum uric acid may not be the negative prognostic factor in AMI, but with the past history of IHD or stroke and in the presence of heart failure the serum uric acid may be of some significance.