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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 9, Issue 2, December 2013 pp 258-266
A Study of Lipid Profile in Iron Deficiency Anemia
Venkateshwarlu Nandyala1, Gandiah P.2, Karthik R.S.3, Sivarajappa P.4, Indira G.5, Krishna Prasad T.6
1,4,5Professor, 2Professor and HOD, 3Ex-Postgraduate Student, 6Assistant Professor
Department of Internal Medicine, SVS Medical College, Mahabubnagar, Andhra Pradesh, INDIA.
Academic Editor : Dr. Aher K.R.
Background & objectives: Iron deficiency anemia (IDA) is common disorder of our nation. Dyslipidemia is widely prevalent in India without any socio-economic status. Association of IDA and dyslipidemias were reported in the same individuals or experimental animals. A prospective study was planned to find the changes in serum lipid profile in adult Indian patients with iron deficiency anaemia and the effect of oral iron therapy on them. Material and Methods: 100 patients with iron deficiency anemia and 50 age and sex matched healthy controls, in the age group of 18-35 years were investigated for any possible changes in serum lipid profile i.e., triglycerides, total cholesterol, high density lipoprotein cholesterol, very low density lipoprotein cholesterol and low density lipoprotein cholesterol. The patients were followed up after 3 months of oral iron therapy. Observations and Results: Total cholesterol, TG, LDL, VLDL levels were found to be significantly (<0.001) elevated in IDA group (165.9 ± 11.49, 175.32 ± 27.8, 93.53 ± 10.65, 31.74 ± 2.96 ) as compared to controls ( 149.04 ± 11.24, 103.28 ± 10.38, 80.02 ± 13.71, 20.92 ± 2.72 ) whereas HDL level was significantly(<0.001) decreased in IDA group (37.27 ± 3.07) compared to controls (48.34 ± 5.43 ). However after treatment there was significant reduction in TG and VLDL levels ( 87.78 ± 5.75 and 19.83 ± 1.95 ) when compared to their pre-treatment levels ( 175.32 ± 27.8 and 31.74 ± 2.96 ) and significant increase inHDL level ( 46.5 ± 3.58 ) as compared to pre-treatment levels ( 37.27 ± 3.07 ), whereas Total cholesterol and LDL levels (153.06 ± 15.2 and 88.76 ± 16.18) reduced insignificantly compared to pre-treatment levels (165.9 ± 11.49 and 93.53 ± 10.65 ). Conclusion: This study indicates that iron deficiency anaemia in Indian adults is attended by abnormal serum lipid profile, which responds significantly to iron therapy.