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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 9, Issue 2, December 2013 pp 290-294
Evaluation of Antidepressant like Activity of Aqueous Extract of Fruits of Emblica officinalis (Amla) in Albino Mice
Nagapati Prabhakar Bhat1, Parashivamurthy B. M.2
1Assistant Professor, Department of Pharmacology, Adichunchanagiri Institute of Medical sciences, B. G. Nagar, Karnataka-571448 INDIA.
2Professor and Head, Department of Pharmacology, Mysore Medical College and Research Institute, Mysore, Karnataka- 570001 INDIA.
Academic Editor : Dr. Aher K.R.
Introduction: Depression is a disorder of the brain. There are a variety of causes, including genetic, environmental, psychological and biochemical factors. Currently, the available anti-depressant agents are associated with unwanted side effects and have their own limitations. An increasing number of herbal products have been introduced into psychiatric practice, as alternative or complementary medicines. The added advantages of indigenous medicinal treatment would include its complementary nature to the conventional treatment making latter safer, well tolerated and economical remedy for depressive disorders. Aim: To evaluate the antidepressant activity of amla (Emblica officinalis) in albino mice and compare it with imipramine. Method: Swiss albino mice weighing around 20 g – 40 g of either sex were divided into five treatment groups and orally administered with gum acacia (control), imipramine 15mg/kg (standard), amla 2mg/kg and 4mg/kg (test drugs) and combination of imipramine and amla. Total of 60 animals were used. Each group contained 6 animals. Duration of immobility was observed for 4 minutes of total 6 minutes period in tail suspension test and in forced swimming test on separate set of animals on 1st day, 8th day and 15th day. Study Design: animal study in mice using two animal models - Tail suspension test and Forced swimming test. Results: Results were analyzed by factorial repeated measure ANOVA and multivariate statistical tests. Amla at the above doses significantly reduced the immobility time in both the tests compared to control (p < 0.05). The reduction in duration of immobility at the dose of 4mg/kg was comparable to imipramine. Conclusion: The aqueous extract of fruits of amla (Emblica officinalis) has significant antidepressant activity in animal models of depression.