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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 9, Issue 3, January 2014 pp 337-340

Research Article

Chronic Osteomyelitis: Aetiology and Antibiotic Susceptibility Pattern

 Mita D. Wadekar1, Venkatesha D.2, Anuradha K.3

1Assistant professor, Department of Microbiology, Subbaiah Institute of Medical Sciences, Shimoga, Karnataka, INDIA.

{2Associate Professor, 3Professor and Head, Department of Microbiology}

Mysore Medical College and Research Institute, Mysore, Karnataka, INDIA.

Academic Editor : Dr. Aher K.R.



Background: Chronic osteomyelitis is a persistent disease, difficult to treat or eradicate completely. In the absence of early diagnosis and prompt treatment or due to development of drug resistance, chronic osteomyelitis is still an important cause of high morbidity. Pus culture and sensitivity will yield the causative organism and help in selecting the appropriate antibiotics. Methodology: 100 pus samples taken aseptically were cultured on Blood and MacConkey agar plates aerobically at 37oC for 18-24 hrs. Culture isolates were identified by a series of standard biochemical reactions. Antibiotic susceptibility was performed as per CLSI guidelines. Results: Study group comprised73males and 27 females. Majority of the patients were in the age group of 11 – 50 years (77%) with trauma being the most common (44%) predisposing factor. The commonest organisms isolated were Staphylococcus aureus (35%) and Pseudomonas aeruginosa (17%). Majority of Gram positive organisms were sensitive to Amikacin, Linezolid, Vancomycin and Gram negative organisms to Amikacin and Imipenem. Conclusion: The wide range of causative organisms and degree of resistance to commonly used anti-microbials supports the importance of pus culture and provides important information to guide clinician’s choice of empirical antibiotics.