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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 9, Issue 3, January 2014 pp 378-385

Research Article

Histogenesis of Human Fetal Renal Cortex


Rahul Kisan Ukey*, Abdur Rafe Abdul Waheed1, Mohammad Laeeque2, C.V. Diwan3

*Assistant professor, 1Assistant professor, 2Assistant professor, 3Professor and Head

Department of Anatomy, Government Medical College, Aurangabad, 431001, Maharashtra, INDIA.

Academic Editor : Dr. Aher K. R.



Histogenesis of human fetal kidney throws light upon the histological maturity of kidney and its functional status at a given gestational age. Kidney develops from two sources, ureteric bud and metanephric blastema. Ureteric bud differentiates into the collecting part i.e. collecting tubules and ureter while the metanephric blastema forms secretory part i.e. nephron. Both these parts get fused with each other so as to complete the development. The present study was carried out on 50 aborted human fetuses between 13-36 weeks of gestational age with no obvious congenital anomalies. Cut sections of both kidneys were processed and paraffin blocks prepared. Sections of 5-7 micron thick were taken, mounted and stained with Haematoxylin and Eosin, Masson’s trichrome and Periodic acid-schiff stains. Microscopic features were observed and documented. The kidney showed lobulations which fused completely at 16 weeks, histologically. Nephrogenic zone was seen up to 32 weeks. The glomeruli passed through various stages of development from vesicular to mature form. The primitive forms of glomeruli were seen in the superficial part of the cortex while the most mature of them were seen in the deeper part of the cortex. Vascularity of glomeruli increased with increase in gestational age. With increase in gestational age, Bowman’s capsule became well differentiated. The proximal and distal convoluted tubules were identified in cortex from 16th week onwards. Cortico-medullary differentiation was well pronounced from 16-18 week onwards.