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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 9, Issue 3, January 2014 pp 411-412

Research Article

Diacerein Efficacy in Knee Osteoarthritis: Pain and Structural

Rajesh S. Bhat¹, Chandralekha N.², Harsharaj³

¹Assistant Professor, ³Senior Resident, Department of Orthopedics, Fr. Muller Medical College, Mangalore, Karnataka, INDIA.

Academic Editor : Dr. Aher K. R.

The Aims of this study is to evaluate efficacy of Diacerein and to know whether Diacerein brings about functional as well as structural improvement in osteoarthritis of knee joint. Study Design and Methods: 320 male and female patients within an age range of 35 years to 60 years were selected. This prospective study was done at father Muller medical college Hospital, Kankanady, Mangalore. Diacerein 50 mg tab was administered orally once daily to them for period of four months. All patients with Primary osteoarthritis diagnosed clinically and radiologically {Kellgren-Lawrence grade1-3} were between 35 to 60 years of age. Those patients were excluded from the present study who were of age less than 35 years or more than 60 years, hepatic and renal impairment, were diagnosed to have any inflammatory arthritis, gout or acute trauma of the knee, hip or spine; accompanying OA of the hip of sufficient severity to interfere with the functional assessment of the knee,Pts had previous or ongoing treatment with oral DMOAD (e.g., glucosamine sulphate, chondroitin sulphate, diacerein); pregnant females and those who were planning their pregnancy during the study, known hypersensitivity to diacerein, persistent diarrhoea ; severe gastrointestinal disorders and who received oral, intramuscular, intraarticular injections of corticosteroids within last eight weeks before receiving the first dose of the diacerein, or had undergone joint lavage and arthroscopic procedures in the previous 6 months, were also excluded. Findings: Out of the 320 cases seen for the period of four months all of them improved on the pain scale. Improvements seen on the X-ray images assessd by joint space preservation and increase after four months of diacerein therapy were the characteristic findings. Interpretation: We can conclude from the results that Diacerein is very useful, disease modifying drug for Osteoarthritic patients bringing about structural and functional changes in the joints of OA patients with less adverse effects.