Mahendra T Kamble, Prashant V Dharme, Prerna D Nandedkar, Arvind V Gaikwad, Kamalakar B Mane
Background: Suicidal ideation is common in major depressive disorder, and it is thought to be a strong contributing factor for completed or attempted suicide. Hyperglycemia and hyperinsulinemia may increase the risk of depression and also suicide risk. Therefore this study was conceived to explore the possible relationship between suicidal behaviour and impaired glucose metabolism in major depressive disorders. Materials and Method: This study was undertaken in Department of Biochemistry and Psychiatry, Government Medical College, Nagpur. 60 diagnosed cases of major depressive disorder in the age range of 21-60 years of either sex were enrolled. The diagnosis was determined by DSM IV criteria. HAMD scale was used to assess the severity of depression. Fasting and postprandial blood glucose along with HbA1c was determined in the study participants. Results: Out of 60 patients, nearly more than half of (53.33%, n=32) patients were having suicidal ideation and attempt. The male depressive cases (73.33%, n=22) outnumbered the female depressive cases (33.33%, n= 10) in having suicidal ideation and attempt. Statistically significant differences were found in fasting, postprandial blood glucose and HbAa1c of the major depressive cases with no suicidal ideation and behaviour, and with suicidal ideation and attempt. Conclusion: The observed association between blood glucose levels, HbA1c and suicidal behaviour suggests that disturbances in glucose metabolism are associated with suicidal ideation and attempts
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Yashdeep, Kishor Singh, Sanjay Kanodia, Parvesh
A study of the cutaneous manifestations in patients of diabetes mellitus
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Endocrinol Metab Clin North Am. 1996; 25:463-72. 21. Muller SA. Dermatologic disorders associated with diabetes mellitus. Mayo Clin Proc. 1966; 41:689-703. 22. Jelinek J E. Cutaneous Manifestations of Diabetes Mellitus. Int J Dermatol. 1994; 33(9):605- 17. 23. Levy L, Zeichner JA. Dermatologic manifestation of diabetes. J Diabetes. 2012; 4(1):68-76. 24. Mutairi N. Skin diseases seen in diabetes mellitus. Bulletin of the Kuwait Institute for Medical Specialization. 2006; 5:30-9. 25. Libecco JF, Brodell RT, Finger Pebbles and Diabetes: A Case with Broad Involvement of the Dorsal Fingers and Hands. Arch Dermatol. 2001; 137(4):510-1. 26. Huntley AC. Finger pebbles: A common finding in diabetes. J Am Acad Dermatol. 1986; 14:612-7. 27. Cabo H, Woscoff A. Cutaneous manifestations of diabetes mellitus. J Am Acad Dermatol.1995; 32(4):685. 28. Sreedevi C, Car N, Renar IP. Dermatologic lesions in diabetes mellitus. Diabetologia Croatica. 2002; 31 (3): 147-59. 29. Van Hattem S, Bootsma AH, Thio HB. Skin manifestations of diabetes. Cleve Clin J Med. 2008 Nov; 75(11):772-7. 30. Grandhe NP, Bhansali A, Dogra S, Kumar B. Acanthosis nigricans: Relation with type 2 diabetes mellitus, anthropometric variables, and body mass in Indians. Postgrad Med J. 2005; 81 :541-4. 31. Crook MA. Skin tags and the artherogenic lipid profile. J Clin Pathol. 2000; 53:873-4. 32. Kahn CR, Flier JS, Bar RS, Archer JA, Gorden P, Martin MM, et al. The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med. 1976 Apr 1; 294(14):739-45. 33. Kahana M, Grossman E, Feinstein A, Ronnen M, Cohen M, Millet MS. Skin tags: A cutaneous marker for diabetes mellitus. Acta Derm Venereol. 1987; 67: 175-7. 34. Thappa DM. Skin tags as markers of diabetes mellitus: An epidemiological study in India. J Dermatol I 995; 22( 10):729-31. 35. Jowkar F, Fallahi A, Namazi MR. Is there any relation between serum insulin and insulin- like growth factor-l in non-diabetic patients with skin tag. J Eur Acad Dermatol Venereol. 2010; 24:73-4. 36. Gupta D, Hess B, Bachegowda L. Granuloma Annulare. The Scientific World Journal. 2010; 1:384-6. 37. Dornelles SI, Poziomczyk CS, Boff A, Koche B, Dornelles Mde A, Richter GK, et al Generalized perforating granuloma annulare. An Bras Dermatol 2011; 86(2):327 -31. 38. Yamaoka H, Sasaki H, Yamasaki H, Ogawa K, Ohta T, Furuta H, et al. Truncal pruritus of unknown origin may be a symptom of diabetic polyneuropathy. Diabetes Care. 2010; 33:150-5. 39. Cantbell AR, Martz W. Idiopathic bullae in diabetics: bullosis diabeticorum. Arch Dermatol 1967; 96:42-4. 40. NamaziI MR, Jorizzo JL, Fallahzadeh MK. Rubeosis Faciei Diabeticorum: a Common, but Often Unnoticed, Clinical Manifestation of Diabetes Mellitus. Scientific World Journal. 2010; 1 0:70-1.
A V Salunkhe, U U Joshi, N R Mudiraj
Background: Myocardial infarction is the most important cause of mortality and morbidity in the world. Dermatoglyhics is the scientific study of skin creases and lines and has formed an important part of surface anatomy. The development of dermatoglyphics occurs at much earlier embryonic stage at which most of the organs and systems develop including the cardiovascular system. Hence in this study we evaluated the dermatoglyphics in patients of Myocardial Infarction as compared to normal counterparts. Materials and Methods: Study was carried out in Department of Anatomy, in D. Y. Patil medical college during January 2011 to June 2012. Finger prints and palm prints of 150 diagnosed cases of Myocardial Infarction 120 males (M) and 30 females (F) and 150 Control group120 males and 50 females were obtained. Standard ink method was used for data collection of both the hands. Written consent of the patients were obtained. Results: Significant increase in the mean value of ‘atd’ angle in both sexes in myocardial infarction patients was observed as compared to controls. Conclusion: From the present study, it appears that there exists a specific relation in the ‘atd angle’ and Myocardial infarction patients, as compared to normal subjects. It warrants further research in the same direction.
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Pratibha Mittal, Anshu Sharma
Blood stream infection are major public health problem which leads to high morbidity and mortality of patients. So for on time diagnosis and appropriate treatment, total 214 blood samples received in microbiology laboratory from tertiary care hospital of R.N.T medical college, Udaipur over the duration of one year. Blood samples collected in BHI broth and the growth obtained was identified by colony morphology, grams staining of isolated colonies and by conventional biochemical tests as per the standard protocol followed in our laboratory and then antibiotic susceptibility test done of isolated colony. Positive blood cultures were obtained in 54.6% of total cases of which Gram-positive bacteria accounted for 61% of cases with staph. aureus predominance, gram negative bacteria accounted for 28% with the predominance of Escherichia coli, klebseilla sp. and pseudomonas sp. and 11.1 % were fungal isolates. The most sensitive drugs for Gram-positive isolates were Amikacin, Ciprofloxacin, Doxycycline, Levofloxacin, Tetracycline and for Gram-negative were Levofloxacin, Tetracycline, Doxycycline and Ciprofloxacin.
1. Wasihun AG, Wlekidan LN, Gebremariam SA, Dejene TA, Welderufael AL, Dejenie TD, and Muthupandian S:Bacteriological profile and antimicrobial susceptibility patterns of blood culture isolates among febrile patients in Mekelle Hospital, Northern Ethiopia: SpringerPlus. 2015; 4:314. 2. Patricia M. Tille: Bailey and Scott’s Diagnostic Microbiology Fourteenth Edition. 3. Diekema DJ, Beekmann SE, Chapin KC, Morel KA, Munson E, Doern GV:Epidemiology and outcome of nosocomial and community-onset bloodstream infection:J Clin Microbiol 2003;41:3655-60. 4. Mehdinejad M, Khosravi AD, Morvaridi A: Study of prevalence and antimicrobial susceptibility pattern of bacteria isolated from blood cultures: J Biologic Sci. 2009; 9:249-53. 5. Shrestha S, Amatya R: Frequency of blood culture isolates and their antibiogram in a teaching hospital:J Nepal Med Assoc.2014;52(193):692-6. 6. Garg A, Anupurba S, and Garg J: Bacteriological profile and antimicrobial resistance of blood culture isolates from a university hospital:J Ind Acad Clin Med.2007; 8(2):139–143. 7. Vanitha RN, Kannan G, Venkata NM, Vishwakanth D, Nagesh VR, Yogitha M et al:A retrospective study on blood stream infections and antibiotic susceptibility patterns in a tertiary care teaching hospital:Int J Pharm Sci.2012;4:543-8. 8. Clinical and Laboratory Standards Institute.Performance Standards for Antimicrobial Susceptibility Testing. Twenty-Second Informational Supplement.Wayne, PA, USA: Clinical and Laboratory Standards Institute; 2012. M100-S22. 9. Tiwari P, Kaur S: Profile and sensitivity pattern of bacteria isolated from various cultures in a Tertiary Care Hospital in Delhi: Indian J Public Health. 2010; 54:213-5. 10. Oza SS, Mehta JS, kikani KM, Oza GS:Bacteriological profile and antibiogram of blood culture isolates from patients of rural tertiary care hospital: Int J Microbiol Myco.2016;4(3): 1-7. 11. 12.Lee,A,S.Mirrett,L.B.Reller and M.P.Weinstein:Detection of bloodstream infections in adults,How many blood cultures are needed?:J Clin Microbiol.2007;45:3546-3548. 12. China and Gupta V: Bacteriological profile and antimicrobial susceptibility pattern of blood isolates from a tertiary care hospital in North India:Int J Pharm Sci Res.2013;2: 24–35, 2013. 13. Kamga HLF, Njunda AL and Nde PF:Prevalence of septicemia and antibiotic sensitivity pattern of bacterial isolates at the University Teaching Hospital:Afr J Cln Exper Microbiol.2011;12(1):2–8. 14. Sharma R, Sharma R and Gupta S: Bacteriological Analysis of Blood Culture Isolates with their Antibiogram from a Tertiary Care Hospital:Int J Pharm Sci Res.2015;6(11): 4847-5. 15. Mehta M, Dutta P, and Gupta V: Antimicrobial susceptibility pattern of blood isolates from a teaching hospital in North India: J Infect Dis.2005; 58(3):174–176. 16. Roy, Jain A, Kumar M, and Agarwal SK:Bacteriology of neonatal septicemia in a tertiary care hospital of Northern India:Indian J Med Microbiol.2002;20:156–159. 17. Devi V, Sahoo B, Damrolien S, Praveen S, Lungran P, Devi M:A study on the bacterial profile of bloodstream infections in Rims Hospital:J Dent Med Sci.2015;14:18-23. 18. Karlowsky A, Jones ME, Draghi DC, Thornsberry C, Sahm DF, and Volturo GA: Prevalence and antimicrobial susceptibilities of bacteria isolated from blood cultures of hospitalized patients in the United States: Ann Clin Microbiol Antimicrob.2004; 3(7). 19. Radji M, Fathni R, Fauziyah S: Evaluation of surgical antibiotic prophylaxis in tertiary care hospital in jakarta Indonesia:Experi J.2014;18(4):1292-6. 20. Vera VP, Igor F, Goran P, Novak S, Abram M, Ulf Bergman:Antimicrobial use at a university hospital: appropriate or misused? A qualitative study:Int J Clin Pharmacol Ther. 2007;45(3):169-74.
Swati Chavan, Rupal Padhiyar, Aniket Mohite, Swapnil Dhampalwar
Objectives: Acute respiratory failure frequently necessitates the introduction of endotracheal tube to maintain airway patency and for mechanical ventilation. Intubation is a procedure in day today practice in EMS, medical wards, operation theatres. This is study done retrospectively of 200 patients to correlate the factors which affect outcome of intubation age, sex, nature of underlying disease. The purpose of this study is also to determine whether intubation alone or subsequent tracheostomy in previously intubated patients can prognosticate outcome and the complications of endotracheal intubation and tracheostomy as acquired either during the procedure, with tube in situ or on extubation. Methods: A retrospective study of 200 adult patients was conducted, who satisfied inclusion and exclusion criteria for intubation on elective or emergency grounds over a period of 18 months. Patient’s demographic data along with lab tests of Sr. Creatinine, Sr. K+, ABG analysis, chest X-ray, Mallampatti grade was noted. The indication for intubation as elective or emergency was based on ABG or severity of respiratory failure or for tracheal toileting. SOFA score, GCS score at Admission and 48 hrs was noted. Results: In this study, 200 patients were intubated. Out of which 137 were elective and 63 emergency and 146 were Males and 54 were Females. Major age group was 21- 40 years. Organ involvement in form of respiratory (168 patients), hepatic(19 patients), renal failure(44 patients) or MODS (18 patients) didn’t affect outcome in these patients. The overall mortality rate of the study was 37%. The disease specific mortality for sepsis patients was 100%, Coma was 56.2% and pneumonia was 52.4%. The elective intubated patients had lower mortality (32.1%) compared to that of emergency intubated patients (47.6%). Conclusion: Patients have to be intubated electively and early tracheostomy at 72- 96 hrs has improved survival.
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L M Lenora, D Suresh Babu, R Sumathi, A Mayavel, S Murugesan, N Senthilkumar
Anthocyanin from red tamarind, Tamarindus indica var. rhodocarpa as a potential natural pigment for use in textile industry
1. Chandan Kumar Jha, Ratan Kumar, Venkat Kumar S and Devi Rajeswari V: Extraction of natural dye from marigold flower (Tageteserectal.) and dyeing of fabric and yarns: A focus on colorimetric analysis and fastness properties: Der Pharmacia Lettre. 2015; 7 (1):185-195. 2. Kundal J, Singh SV, Purohit MC: Extraction of Natural Dye from Ficus cunia and Dyeing of Polyester Cotton and Wool Fabric Using Different Mordants, with Evaluation of Colour Fastness Properties: Nat Prod Chem Res. 2016; 4: 214. 3. Mohammad Gias Uddin: Extraction of ecofriendly natural dyes from mango leaves and their application on silk fabric: Textiles and Clothing Sustainability. 2015; 1:7.
V S Prasannakumar Reddy, Aradhana Giri, N Bhavani, Togarikar
Background: Doppler velocimetry is a rapid non invasive test that provides valuable information about hemodynamic situation of the fetus and is an efficient diagnostic test of fetal jeopardy which helps in timely intervention and management of high risk pregnancy for better perinatal outcome. Material and Methods: This is a prospective study including 40 women with normal singleton pregnancy and 40 women with Intra uterine growth restricted pregnancy carried out over a period of 1 year from april 2015 to march 2016 at MNR Medical College and Hospital, Sangareddy. Results: Umbilical artery mean pulsatility index and resistive index were significantly greater in IUGR pregnancy as compared to normal pregnancy. Systolic/diastolic (S/D) ratios were comparable in both the groups. There was significant reduction in cerebroumbilical (C/U) ratio in IUGR pregnancy as compared to normal pregnancy suggesting presence of a brain sparing effect. 17.5% patients in study group had absent end diastolic volume (AEDV) and 2.5% had reversal of end diastolic volume. Conclusion: In normal pregnancy, there is gestational age related fall in impedance in umbilical and middle cerebral arteries. Doppler study of umbilical artery is highly sensitive in the detection of IUGR while Middle cerebral artery doppler is useful for the prediction of adverse perinatal outcome in small for gestational age.
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Shilpa Premkumar, Prema Saldanha
Background: Tumours of adipose tissue form one of the largest single groups of soft tissue tumours. The benign, subcutaneous lipoma is the most common soft tissue neoplasm in adults, liposarcoma being the most common primary soft tissue malignancy. Objective: To study the morphological features of the various adipocytic tumours received in the Department of Pathology. Materials and Methods: Cases of adipocytic tumours were retrieved from the archives of the Department of Pathology. Results: The total number of cases numbered 155. Amongst these, 143 (92%) were benign and 12 (8%) were malignant. In benign cases, patients were in the age group 4-75 years, with 88 males and 55 females. Among the malignant cases, patients were in the age group 14-68 years, with 7 males and 5 females. The peak age distribution in both benign and malignant cases was in the fourth decade. The most common site of involvement was the nape of neck, followed by back and upper limbs. Conventional lipoma was the most common benign tumour. Variants of lipoma like angiolipoma, chondroid lipoma, dermolipoma etc was noted. Of the 12 malignant tumours, 6 cases were well differentiated liposarcoma, 2 cases variant of myxoid liposarcoma, and one case each of pleomorphic liposarcoma, lipoleiomyosarcoma and lipoma with sarcomatous changes. Conclusion: Conventional lipomas were the most common adipocytic soft tissue tumours. Malignant cases were rare, and among them, the most common malignant tumour was well-differentiated liposarcoma.
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Natasha Sawhney, Rahul Prabhas, Varsha A Singh
Background: Pregnancy causes numerous changes in the woman’s body. Hormonal and mechanical changes increase the risk of urinary stasis and vesicoureteral reflux. These changes, along with an already short urethra and difficulty with hygiene due to a distended pregnant belly, increase the frequency of urinary tract infections (UTIs) in pregnant women. Indeed, UTIs are among the most common bacterial infections during pregnancy, Urinary tract infections remain one of the most common infections and a leading cause of morbidity in human population. Aims and Objectives: To study Bacteriological Profile of Urinary Tract Infections in Pregnant women at a Tertiary health care center Methodology: This was a cross-sectional study carried out in the department of Microbiology in association with department of Obstetrics and Gynaecology of a tertiary health care center during one year period i.e. March 2013 to March 2014 in 280 Samples of Suspected UTI in pregnant women. Fifty six samples were culture positive and were addressed for Antibiotic Sensitivity Testing (AST) as per the standard protocols. Results: The most commonly observed bacteria was E. coli (39.29%) and Staphylococcus aureus (19.64%), followed by Coagulase negative staphylococcus (16.07%), Klebsiella sp. (12.50%), Enterococci sp. (8.93%) and Acinetobacter sp. (3.57 %). Escherichia coli was most commonly sensitive to Nitofurantoin (77.27%), Klebsiella to Norfloxacin (71.43%), and Acinetobacter was 100% senstive to Amoxiclav, Amikacin, Tetracyclines and Norfloxacin. In Gram positive pathogens, Staphylococcus aureus was mostly sensitive to Cotrimoxazole and Erythromycin. Conclusion: It can be concluded from our study that commonly observed bacteria were E. coli and Staphylococcus aureus causing UTI in pregnant women. All pregnant women should be screened for UTI with a urine culture and treated with antibiotics if the culture is positive
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